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Efficacy and Safety

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A faster improvement in clinical signs has been observed compared to benazepril alone 1,2,3

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Improvement of heart failure symptoms: difference between the time to improvement observed in dogs treated with benazepril alone versus dogs treated with CARDALIS™ (significant difference p<0.05).

…and safe when used with concomitant therapy(e.g., furosemide)4

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Renal parameters mean values:

• remained within the reference range
• did not change significantly over the 12-month study duration

The BESST Study - a pivotal efficacy study for FDA approval of CARDALIS™5

dog-icon 569 dogs enrolled in the study
 

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* Treatment failure = occurrence of cardiac death/euthanasia due to cardiac cause or worsening/occurrence of cardiac signs

LARGEST CLINICAL TRIAL CONDUCTED TO DATE IN CARDIAC DOGS

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CARDALIS resulted in a statistically significant improvement in survival times for CHF patients* in a recently completed clinical trial5.

 

 

 

 

Cardalis Palatability

for patient compliance

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References 

  1. Data on file: Cardalis™. Marketing authorization file, CEVA Santé Animale, 2012.
  2. Cardalis™. CVMP assessment report. EMA. August 2012. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_Public_assessment_report/veterinary/002524/WC500131472.pdf
  3. Cardalis™. EPAR product information. June 2013. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/veterinary/002524/WC500131473.pdf.
  4. Freedom of Information Summary, NADA #141-538 (July 27, 2020), CARDALIS.
  5. Coffman, M Guillot, E Blondel, T, et al. Clinical efficacy of a benazepril and spironolactone combination in dogs with congestive heart failure due to myxomatous mitral valve disease: The BEnazepril Spironolactone STudy (BESST)J Vet Intern Med 2021 1 15
    https://doi.org/10.1111/jvim.16155

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